LTA4H

Entrez Summary: N/A
UniProt Summary: Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. {ECO:0000269|PubMed:11917124, ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870, ECO:0000269|PubMed:18804029, ECO:0000269|PubMed:1897988, ECO:0000269|PubMed:1975494, ECO:0000269|PubMed:2244921}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Leuk-A4-hydro C
Peptidase M1

leukotriene-A4 hydrolase activity
epoxide hydrolase activity
leukotriene biosynthetic process
metalloaminopeptidase activity
aminopeptidase activity
long-chain fatty acid biosynthetic process
peptide catabolic process
leukotriene metabolic process
icosanoid biosynthetic process
tertiary granule lumen
peptidase activity
fatty acid derivative biosynthetic process
icosanoid metabolic process
long-chain fatty acid metabolic process
fatty acid biosynthetic process
ficolin-1-rich granule lumen
fatty acid derivative metabolic process
monocarboxylic acid biosynthetic process
carboxylic acid biosynthetic process
organic acid biosynthetic process
fatty acid metabolic process
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
peptide metabolic process
monocarboxylic acid metabolic process
lipid biosynthetic process
myeloid leukocyte activation
small molecule biosynthetic process
leukocyte activation involved in immune response
cell activation involved in immune response
regulated exocytosis
leukocyte mediated immunity
cellular amide metabolic process
exocytosis