LTB

Entrez Summary: N/A
UniProt Summary: Cytokine that binds to LTBR/TNFRSF3. May play a specific role in immune response regulation. Provides the membrane anchor for the attachment of the heterotrimeric complex to the cell surface. Isoform 2 is probably non-functional.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Myriocin 25μM R06 exp293	1.7
CHIR-124 0.04μM R06 exp272	1.79

positive regulation of interleukin-12 biosynthetic process
regulation of interleukin-12 biosynthetic process
lymph node development
tumor necrosis factor receptor binding
positive regulation of interleukin-12 production
regulation of interleukin-12 production
positive regulation of cytokine biosynthetic process
regulation of cytokine biosynthetic process
tumor necrosis factor-mediated signaling pathway
cytokine activity
cellular response to tumor necrosis factor
response to tumor necrosis factor
signaling receptor binding
skin development
positive regulation of cytokine production
cellular component
hematopoietic or lymphoid organ development
immune system development
cytokine-mediated signaling pathway
regulation of cytokine production
cellular response to cytokine stimulus
response to cytokine
cell-cell signaling
extracellular space
positive regulation of protein metabolic process
positive regulation of multicellular organismal process
immune response
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
gene expression
positive regulation of biosynthetic process