LXN

Entrez Summary: N/A
UniProt Summary: Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4. May play a role in inflammation. {ECO:0000269|PubMed:15738388}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

detection of temperature stimulus involved in sensory perception of pain
detection of temperature stimulus involved in sensory perception
metalloendopeptidase inhibitor activity
detection of temperature stimulus
sensory perception of temperature stimulus
sensory perception of pain
detection of external stimulus
detection of abiotic stimulus
heparin binding
response to temperature stimulus
negative regulation of endopeptidase activity
negative regulation of peptidase activity
negative regulation of proteolysis
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
inflammatory response
detection of stimulus involved in sensory perception
detection of stimulus
regulation of proteolysis
negative regulation of catalytic activity
sensory perception
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
response to abiotic stimulus
regulation of hydrolase activity
defense response
nervous system process
extracellular space
system process