LZTS3

Entrez Summary: N/A
UniProt Summary: May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses. {ECO:0000250|UniProtKB:Q8K1Q4}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of dendritic spine morphogenesis
regulation of dendritic spine development
regulation of dendrite morphogenesis
regulation of postsynapse organization
regulation of dendrite development
postsynaptic membrane
regulation of synapse organization
regulation of synapse structure or activity
postsynaptic density
synapse
regulation of cell morphogenesis involved in differentiation
cytoskeleton
regulation of cell morphogenesis
regulation of neuron projection development
cell junction
regulation of neuron differentiation
regulation of plasma membrane bounded cell projection organization
regulation of cell projection organization
regulation of neurogenesis
regulation of nervous system development
regulation of cell development
regulation of anatomical structure morphogenesis
generation of neurons
neurogenesis
regulation of cell differentiation