MAGED2
Gene Information
- Official Symbol: MAGED2
- Official Name: MAGE family member D2
- Aliases and Previous Symbols: N/A
- Entrez ID: 10916
- UniProt: Q9UNF1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene is a member of the MAGED gene family. The MAGED genes are clustered on chromosome Xp11. This gene is located in Xp11.2, a hot spot for X-linked intellectual disability (XLID). Mutations in this gene cause a form of transient antenatal Bartter's syndrome. This gene may also be involved in several types of cancer, including breast cancer and melanoma. The protein encoded by this gene is progressively recruited from the cytoplasm to the nucleoplasm during the interphase and after nucleolar stress and is thus thought to play a role in cell cycle regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017].
- UniProt Summary: Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule. {ECO:0000269|PubMed:27120771}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 10568
- Expression level (log2 read counts): 5.09
MAGED2 Expression in NALM6 Cells: 5.09
