MAP1B
Gene Information
- Official Symbol: MAP1B
- Official Name: microtubule associated protein 1B
- Aliases and Previous Symbols: N/A
- Entrez ID: 4131
- UniProt: P46821
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing. {ECO:0000250, ECO:0000269|PubMed:18195017}.
Pfam Domains GO Terms
Pfam Domains
| MAP1B neuraxin |
GO Terms
| hippocampal mossy fiber |
| induction of synaptic plasticity by chemical substance |
| regulation of synaptic plasticity by chemical substance |
| positive regulation of synaptic plasticity by chemical substance |
| peripheral nervous system axon regeneration |
| basal dendrite |
| varicosity |
| positive regulation of synaptic plasticity |
| somatodendritic compartment |
| apical dendrite |
| response to insecticide |
| response to vitamin A |
| establishment of mitochondrion localization, microtubule-mediated |
| mitochondrion transport along microtubule |
| establishment of monopolar cell polarity |
| establishment or maintenance of monopolar cell polarity |
| axon regeneration |
| establishment of mitochondrion localization |
| negative regulation of microtubule depolymerization |
| regulation of microtubule depolymerization |
| neuron projection regeneration |
| positive regulation of microtubule polymerization |
| microtubule associated complex |
| positive regulation of microtubule polymerization or depolymerization |
| axon extension |
| negative regulation of microtubule polymerization or depolymerization |
| positive regulation of axon extension |
| mitochondrion localization |
| response to axon injury |
| regulation of microtubule polymerization |
| tubulin binding |
| photoreceptor outer segment |
| negative regulation of intracellular transport |
| neuron projection extension |
| negative regulation of protein depolymerization |
| negative regulation of protein complex disassembly |
| organelle transport along microtubule |
| regulation of microtubule polymerization or depolymerization |
| regulation of protein depolymerization |
| positive regulation of axonogenesis |
| response to vitamin |
| developmental cell growth |
| cell growth |
| microtubule bundle formation |
| synapse assembly |
| regulation of axon extension |
| cell projection |
| dendrite development |
| phospholipid binding |
| regulation of extent of cell growth |
| regulation of protein complex disassembly |
| developmental growth involved in morphogenesis |
| establishment of cell polarity |
| neuron migration |
| positive regulation of protein polymerization |
| growth cone |
| negative regulation of supramolecular fiber organization |
| perikaryon |
| response to estradiol |
| negative regulation of cytoskeleton organization |
| dendritic spine |
| positive regulation of cell morphogenesis involved in differentiation |
| regeneration |
| transport along microtubule |
| positive regulation of cell growth |
| positive regulation of developmental growth |
| response to carbohydrate |
| cytoskeleton-dependent intracellular transport |
| regulation of cell size |
| microtubule-based transport |
| regulation of axonogenesis |
| regulation of microtubule cytoskeleton organization |
| regulation of synaptic plasticity |
| structural molecule activity |
| establishment or maintenance of cell polarity |
| positive regulation of supramolecular fiber organization |
| response to mechanical stimulus |
| response to nutrient |
| positive regulation of cytoskeleton organization |
| regulation of microtubule-based process |
| regulation of protein polymerization |
| microtubule binding |
| developmental maturation |
| positive regulation of protein complex assembly |
| postsynaptic density |
| positive regulation of growth |
| cellular response to peptide hormone stimulus |
| protein-containing complex binding |
| synapse |
| actin binding |
| synapse organization |
| microtubule-based movement |
| positive regulation of neuron projection development |
| axon |
| regulation of cell morphogenesis involved in differentiation |
| microtubule |
| cellular response to peptide |
| regulation of developmental growth |
| regulation of supramolecular fiber organization |
| regulation of intracellular transport |
| establishment of organelle localization |
| positive regulation of neuron differentiation |
| axonogenesis |
| neuronal cell body |
| negative regulation of organelle organization |
| regulation of cellular component size |
| positive regulation of cell projection organization |
| developmental growth |
| response to peptide hormone |
| growth |
| axon development |
| regulation of cell growth |
| dendrite |
| cell morphogenesis involved in neuron differentiation |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| regulation of protein complex assembly |
| positive regulation of neurogenesis |
| response to peptide |
| microtubule cytoskeleton organization |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| negative regulation of transport |
| cell projection morphogenesis |
| regulation of cell morphogenesis |
| regulation of neuron projection development |
| response to nutrient levels |
| cellular response to growth factor stimulus |
| response to toxic substance |
| regulation of anatomical structure size |
| cell part morphogenesis |
| positive regulation of cellular component biogenesis |
| response to extracellular stimulus |
| response to growth factor |
| response to inorganic substance |
| positive regulation of nervous system development |
| regulation of cytoskeleton organization |
| positive regulation of cell development |
| cell junction |
| cell morphogenesis involved in differentiation |
| response to wounding |
| organelle localization |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| positive regulation of organelle organization |
| regulation of neuron differentiation |
| cellular response to nitrogen compound |
| neuron projection development |
| microtubule-based process |
| regulation of growth |
| regulation of plasma membrane bounded cell projection organization |
| perinuclear region of cytoplasm |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| cell morphogenesis |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| response to lipid |
| response to hormone |
| regulation of cellular localization |
| response to organic cyclic compound |
| regulation of nervous system development |
| regulation of cell development |
| regulation of cellular component biogenesis |
| cell migration |
| positive regulation of cell differentiation |
| response to organonitrogen compound |
| neuron differentiation |
| response to drug |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| localization of cell |
| cell motility |
| response to nitrogen compound |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| response to abiotic stimulus |
| cell projection organization |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| regulation of organelle organization |
| locomotion |
| positive regulation of developmental process |
| response to endogenous stimulus |
| intracellular transport |
| generation of neurons |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| neurogenesis |
| cell development |
| cellular response to stress |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
| establishment of localization in cell |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| CCCP 0.1μM R00 exp10 | -2.01 |
| Cycloheximide 0.02μM R00 exp14 | -1.78 |
| Talazoparib 0.006μM R06 exp299 | -1.77 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10427
- Expression level (log2 read counts): 4.89
Expression Distribution
MAP1B Expression in NALM6 Cells: 4.89
