MAP4K2

Entrez Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Dimethyloxaloylglycine 100μM R05 exp229	-1.93
Phenformin 20μM R05 exp212	-1.93
Ibrutinib 1μM R07 exp372	1.85
UNC1999 2μM R03 exp155	1.85

MAP kinase kinase kinase kinase activity
activation of MAPKKK activity
mitogen-activated protein kinase kinase kinase binding
activation of JUN kinase activity
positive regulation of JUN kinase activity
JNK cascade
regulation of JUN kinase activity
vesicle targeting
stress-activated MAPK cascade
positive regulation of JNK cascade
stress-activated protein kinase signaling cascade
activation of MAPK activity
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
establishment of vesicle localization
vesicle localization
regulation of JNK cascade
basolateral plasma membrane
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
positive regulation of MAP kinase activity
activation of protein kinase activity
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity
establishment of organelle localization
protein serine/threonine kinase activity
MAPK cascade
signal transduction by protein phosphorylation
regulation of protein serine/threonine kinase activity
positive regulation of protein kinase activity
positive regulation of MAPK cascade
positive regulation of kinase activity
organelle localization
Golgi membrane
positive regulation of transferase activity
regulation of cellular response to stress
regulation of MAPK cascade
innate immune response
regulation of protein kinase activity
regulation of kinase activity