MAPK8

Gene Information

Official Symbol: MAPK8
Official Name: mitogen-activated protein kinase 8
Aliases and Previous Symbols: N/A
Entrez ID: 5599
UniProt: P45983
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17428
Expression level (log2 read counts): 5.33

Expression Distribution

Screen	Score
KU-0063794 3.8μM R02 exp71	1.82
Nifurtimox 1μM R03 exp141	2.01
BI-2536 0.0042μM R03 exp95	2.27

Pkinase Tyr
Pkinase
Kdo

histone deacetylase regulator activity
regulation of DNA replication origin binding
JUN kinase activity
JUN phosphorylation
basal dendrite
positive regulation of deacetylase activity
regulation of deacetylase activity
MAP kinase activity
positive regulation of cyclase activity
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
regulation of histone deacetylation
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
cellular response to cadmium ion
regulation of protein deacetylation
regulation of cyclase activity
cellular response to amino acid starvation
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
response to amino acid starvation
positive regulation of establishment of protein localization to mitochondrion
response to cadmium ion
regulation of mitochondrial membrane permeability
regulation of establishment of protein localization to mitochondrion
cellular response to mechanical stimulus
kinase activity
regulation of membrane permeability
JNK cascade
peptidyl-threonine phosphorylation
peptidyl-threonine modification
negative regulation of protein binding
stress-activated MAPK cascade
histone deacetylase binding
regulation of circadian rhythm
positive regulation of mitochondrion organization
positive regulation of protein localization to membrane
regulation of DNA binding
mitochondrial membrane organization
cellular response to reactive oxygen species
stress-activated protein kinase signaling cascade
response to UV