MARK4

Gene Information

Official Symbol: MARK4
Official Name: microtubule affinity regulating kinase 4
Aliases and Previous Symbols: N/A
Entrez ID: 57787
UniProt: Q96L34
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Serine/threonine-protein kinase (PubMed:15009667, PubMed:14594945, PubMed:23666762, PubMed:23184942). Phosphorylates the microtubule-associated protein MAPT (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942). {ECO:0000250|UniProtKB:Q8CIP4, ECO:0000269|PubMed:14594945, ECO:0000269|PubMed:15009667, ECO:0000269|PubMed:23184942, ECO:0000269|PubMed:23400999, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:25123532}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5087
Expression level (log2 read counts): 4.98

Expression Distribution

Screen	Score
YM155 0.0002μM R01 exp61	1.81
Taxol 0.002μM R01 exp54	2.22

Pkinase Tyr
Pkinase
KA1

positive regulation of protein localization to centrosome
regulation of protein localization to centrosome
gamma-tubulin complex
tau-protein kinase activity
positive regulation of cilium assembly
gamma-tubulin binding
tau protein binding
regulation of centrosome cycle
positive regulation of organelle assembly
ubiquitin binding
regulation of cilium assembly
microtubule bundle formation
ciliary basal body-plasma membrane docking
positive regulation of plasma membrane bounded cell projection assembly
ciliary basal body
microtubule cytoskeleton
midbody
microtubule organizing center
organelle localization by membrane tethering
membrane docking
regulation of microtubule cytoskeleton organization
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
regulation of organelle assembly
regulation of microtubule-based process
microtubule binding
neuron projection
positive regulation of cellular protein localization
cilium assembly
protein serine/threonine kinase activity
cilium organization
positive regulation of cell projection organization
dendrite
plasma membrane bounded cell projection assembly
cell projection assembly
microtubule cytoskeleton organization
centrosome
cell division
positive regulation of cellular component biogenesis
regulation of cellular protein localization