MCF2

Gene Information

Official Symbol: MCF2
Official Name: MCF.2 cell line derived transforming sequence
Aliases and Previous Symbols: N/A
Entrez ID: 4168
UniProt: P10911
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The oncogenic protein encoded by this gene is a guanine nucleotide exchange factor (GEF) that exerts control over some members of the Rho family of small GTPases. Several transcript variants encoding different isoforms have been found for this gene. These isoforms exhibit different expression patterns and varying levels of GEF activity.[provided by RefSeq, Jan 2010].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18916
Expression level (log2 read counts): 1.9

Expression Distribution

Screen	Score
TIC10 10μM R08 exp532	-1.95
S-trityl-L-cysteine 0.5μM R05 exp243	1.74
Hydroxychloroquine 30μM R08 exp490	1.89
Cyclosporin-A 3μM R07 exp348	1.97

negative regulation of axonogenesis
Rho guanyl-nucleotide exchange factor activity
cellular response to leukemia inhibitory factor
response to leukemia inhibitory factor
negative regulation of cell morphogenesis involved in differentiation
dendrite development
regulation of Rho protein signal transduction
negative regulation of neuron projection development
negative regulation of cell projection organization
regulation of axonogenesis
negative regulation of neuron differentiation
regulation of Ras protein signal transduction
negative regulation of neurogenesis
regulation of cell morphogenesis involved in differentiation
negative regulation of nervous system development
negative regulation of cell development
regulation of small GTPase mediated signal transduction
cytoskeleton
regulation of cell morphogenesis
regulation of neuron projection development
positive regulation of apoptotic process
positive regulation of programmed cell death
regulation of neuron differentiation
neuron projection development
regulation of plasma membrane bounded cell projection organization
positive regulation of cell death
negative regulation of cellular component organization
regulation of cell projection organization
negative regulation of cell differentiation
neuron development
regulation of neurogenesis
regulation of nervous system development
regulation of cell development
negative regulation of developmental process
cellular response to cytokine stimulus
neuron differentiation
regulation of anatomical structure morphogenesis
response to cytokine
plasma membrane bounded cell projection organization
cell projection organization