MDM1

Entrez Summary: N/A
UniProt Summary: Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Mubritinib 0.2μM R01 exp48	-1.82
Ethanol 0.003 R08 exp437	1.79

negative regulation of centriole replication
negative regulation of centrosome duplication
negative regulation of centrosome cycle
regulation of centriole replication
photoreceptor cell maintenance
negative regulation of organelle assembly
regulation of centrosome duplication
regulation of centrosome cycle
retina homeostasis
negative regulation of cytoskeleton organization
retina development in camera-type eye
centriole
regulation of microtubule cytoskeleton organization
tissue homeostasis
regulation of organelle assembly
regulation of microtubule-based process
microtubule binding
camera-type eye development
microtubule
multicellular organismal homeostasis
negative regulation of cell cycle process
anatomical structure homeostasis
eye development
visual system development
sensory system development
negative regulation of organelle organization
centrosome
regulation of cytoskeleton organization
sensory organ development
negative regulation of cell cycle
negative regulation of cellular component organization
regulation of cell cycle process
regulation of cellular component biogenesis
regulation of cell cycle
regulation of organelle organization
homeostatic process