MED26

Entrez Summary: N/A
UniProt Summary: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 399/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	19/28
blood	14/28
bone	11/25
breast	18/33
central nervous system	37/56
cervix	3/4
colorectal	3/17
esophagus	6/13
fibroblast	0/1
gastric	9/15
kidney	8/21
liver	10/20
lung	46/75
lymphocyte	9/14
ovary	13/26
pancreas	13/24
peripheral nervous system	6/16
plasma cell	12/15
prostate	0/1
skin	16/24
soft tissue	4/7
thyroid	2/2
upper aerodigestive	10/22
urinary tract	18/29
uterus	2/5

Expression Distribution

Screen	Score
iCRT14 30μM R08 exp492	-1.77
Colchicine 0.009μM R05 exp215	2.57

core mediator complex
mediator complex
transcription coregulator activity
transcription initiation from RNA polymerase II promoter
DNA-templated transcription, initiation
transcription coactivator activity
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
cellular nitrogen compound biosynthetic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
positive regulation of RNA metabolic process
macromolecule biosynthetic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
gene expression
positive regulation of biosynthetic process