MFGE8

Entrez Summary: N/A
UniProt Summary: Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Binds specifically to rotavirus and inhibits its replication. {ECO:0000250, ECO:0000269|PubMed:19204935}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Sucrose 20000μM R06 exp298	2.13
Menadione 5μM R06 exp292	2.57

F5 F8 type C
EGF

phosphatidylethanolamine binding
extrinsic component of plasma membrane
apoptotic cell clearance
extracellular vesicle
phosphatidylserine binding
positive regulation of phagocytosis
regulation of phagocytosis
phagocytosis, recognition
phagocytosis, engulfment
integrin binding
extracellular matrix structural constituent
plasma membrane invagination
single fertilization
membrane invagination
fertilization
cell recognition
endoplasmic reticulum lumen
angiogenesis
phagocytosis
post-translational protein modification
collagen-containing extracellular matrix
external side of plasma membrane
blood vessel morphogenesis
blood vessel development
vasculature development
cardiovascular system development
regulation of vesicle-mediated transport
endocytosis
tube morphogenesis
import into cell
sexual reproduction
tube development
membrane organization
circulatory system development
anatomical structure formation involved in morphogenesis
cell adhesion
biological adhesion
positive regulation of transport
multi-organism reproductive process
reproductive process