MGAT5

Gene Information

Official Symbol: MGAT5
Official Name: alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase
Aliases and Previous Symbols: N/A
Entrez ID: 4249
UniProt: Q09328
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene belongs to the glycosyltransferase family. It catalyzes the addition of beta-1,6-N-acetylglucosamine to the alpha-linked mannose of biantennary N-linked oligosaccharides present on the newly synthesized glycoproteins. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. Alterations of the oligosaccharides on cell surface glycoproteins cause significant changes in the adhesive or migratory behavior of a cell. Increase in the activity of this enzyme has been correlated with the progression of invasive malignancies. [provided by RefSeq, Oct 2011].
UniProt Summary: Catalyzes the addition of N-acetylglucosamine in beta 1- 6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides. It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13045
Expression level (log2 read counts): 7.9

Expression Distribution

Screen	Score
THZ531 0.11μM R07 exp409	-1.99
FK-506 30μM R07 exp359	-1.92
MKC9989 10μM R03 exp133	1.82

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity
negative regulation of protein tyrosine phosphatase activity
regulation of protein tyrosine phosphatase activity
protein N-linked glycosylation via asparagine
peptidyl-asparagine modification
protein phosphatase inhibitor activity
negative regulation of phosphoprotein phosphatase activity
manganese ion binding
negative regulation of protein dephosphorylation
protein N-linked glycosylation
positive regulation of receptor signaling pathway via STAT
negative regulation of phosphatase activity
negative regulation of dephosphorylation
regulation of phosphoprotein phosphatase activity
regulation of receptor signaling pathway via STAT
regulation of protein dephosphorylation
regulation of phosphatase activity
regulation of dephosphorylation
macromolecule glycosylation
protein glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
negative regulation of hydrolase activity
positive regulation of cell migration
positive regulation of cell motility
positive regulation of cellular component movement
positive regulation of locomotion
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
Golgi membrane
carbohydrate derivative biosynthetic process
negative regulation of catalytic activity
regulation of cell migration
peptidyl-amino acid modification
regulation of cell motility
regulation of locomotion
Golgi apparatus
regulation of cellular component movement