MGST2

Entrez Summary: N/A
UniProt Summary: Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4- dinitrobenzene with reduced glutathione.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Pimelic-diphenylamide-106 0.5μM R00 exp27	1.71
Rifampicin 1μM R00 exp31	1.72
Alpha-Amanitin 0.5μM R00 exp5	2.24

leukotriene-C4 synthase activity
glutathione biosynthetic process
nonribosomal peptide biosynthetic process
leukotriene biosynthetic process
glutathione peroxidase activity
glutathione derivative biosynthetic process
glutathione derivative metabolic process
glutathione transferase activity
leukotriene metabolic process
membrane lipid catabolic process
cellular modified amino acid biosynthetic process
enzyme activator activity
icosanoid biosynthetic process
glutathione metabolic process
cellular oxidant detoxification
fatty acid derivative biosynthetic process
cellular detoxification
icosanoid metabolic process
detoxification
xenobiotic metabolic process
positive regulation of inflammatory response
fatty acid derivative metabolic process
nuclear envelope
sulfur compound biosynthetic process
cellular response to xenobiotic stimulus
cellular lipid catabolic process
cellular modified amino acid metabolic process
membrane lipid metabolic process
cofactor biosynthetic process
cellular response to toxic substance
lipid catabolic process
response to xenobiotic stimulus
carboxylic acid biosynthetic process
organic acid biosynthetic process
response to lipopolysaccharide
response to molecule of bacterial origin
regulation of inflammatory response
sulfur compound metabolic process
peptide biosynthetic process
cofactor metabolic process