MICAL2

Official Symbol: MICAL2
Official Name: microtubule associated monooxygenase, calponin and LIM domain containing 2
Aliases and Previous Symbols: N/A
Entrez ID: 9645
UniProt: O94851
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: The protein encoded by this gene is a monooxygenase that enhances depolymerization of F-actin and is therefore involved in cytoskeletal dynamics. The encoded protein is a regulator of the SRF signaling pathway. Increased expression of this gene has been associated with cancer progression and metastasis. [provided by RefSeq, Oct 2016].
UniProt Summary: Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A- dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA. {ECO:0000250|UniProtKB:Q8BML1, ECO:0000250|UniProtKB:Q8TDZ2, ECO:0000269|PubMed:24440334}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
HMS-I2 10μM R06 exp288	-2.13
TRAIL 5ng/ml R00 exp35	-1.86

NADPH:sulfur oxidoreductase activity
sulfur oxidation
positive regulation of transcription via serum response element binding
NAD(P)H oxidase activity
actin filament depolymerization
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
FAD binding
protein depolymerization
actin polymerization or depolymerization
heart looping
embryonic heart tube morphogenesis
determination of heart left/right asymmetry
embryonic heart tube development
determination of left/right symmetry
oxidoreductase activity
determination of bilateral symmetry
specification of symmetry
cellular protein complex disassembly
protein-containing complex disassembly
actin filament organization
heart morphogenesis
actin binding
embryonic organ morphogenesis
epithelial tube morphogenesis
sulfur compound metabolic process
cellular component disassembly
morphogenesis of an epithelium
embryonic organ development
pattern specification process
supramolecular fiber organization
actin cytoskeleton organization
heart development
tissue morphogenesis
embryonic morphogenesis
actin filament-based process
tube morphogenesis
tube development
circulatory system development
animal organ morphogenesis
oxidation-reduction process