MLKL

Gene Information
  • Official Symbol: MLKL
  • Official Name: mixed lineage kinase domain like pseudokinase
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 197259
  • UniProt: Q8NB16
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: N/A
  • UniProt Summary: Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity. {ECO:0000269|PubMed:22265413, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:22421439, ECO:0000269|PubMed:24316671}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 12600
  • Expression level (log2 read counts): 4.7

Expression Distribution

  • Last modified: 2026/01/07 22:36
  • by 127.0.0.1