MMP15

Entrez Summary: N/A
UniProt Summary: Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A. {ECO:0000269|PubMed:9461298}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

metalloaminopeptidase activity
endodermal cell differentiation
collagen catabolic process
enzyme activator activity
endoderm formation
collagen metabolic process
extracellular matrix disassembly
endoderm development
metalloendopeptidase activity
formation of primary germ layer
response to estradiol
gastrulation
extracellular matrix
extracellular matrix organization
extracellular structure organization
cellular component disassembly
embryonic morphogenesis
zinc ion binding
response to lipid
anatomical structure formation involved in morphogenesis
response to hormone
response to organic cyclic compound
embryo development
proteolysis
integral component of plasma membrane
positive regulation of catalytic activity
response to endogenous stimulus
response to oxygen-containing compound
extracellular space
tissue development
positive regulation of molecular function