MMP3

Gene Information

Official Symbol: MMP3
Official Name: matrix metallopeptidase 3
Aliases and Previous Symbols: N/A
Entrez ID: 4314
UniProt: P08254
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008].
UniProt Summary: Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6430
Expression level (log2 read counts): -7.68

Expression Distribution

Screen	Score
Azithromycin 100μM R08 exp452	-2.16
Demecolcine 0.03μM R05 exp228	-1.76

Hemopexin
PG binding 1
Peptidase M10

negative regulation of hydrogen peroxide metabolic process
negative regulation of cofactor metabolic process
positive regulation of oxidative stress-induced cell death
cellular response to nitric oxide
positive regulation of cellular response to oxidative stress
response to nitric oxide
positive regulation of response to oxidative stress
cellular response to reactive nitrogen species
regulation of hydrogen peroxide metabolic process
positive regulation of protein oligomerization
regulation of neuroinflammatory response
regulation of cofactor metabolic process
collagen catabolic process
regulation of protein oligomerization
response to amyloid-beta
response to bronchodilator
negative regulation of reactive oxygen species metabolic process
regulation of oxidative stress-induced cell death
metallopeptidase activity
collagen metabolic process
extracellular matrix disassembly
regulation of cellular response to oxidative stress
endopeptidase activity
regulation of response to oxidative stress
metalloendopeptidase activity
cellular response to reactive oxygen species
serine-type endopeptidase activity
regulation of reactive oxygen species metabolic process
response to reactive oxygen species
cellular response to inorganic substance
extracellular matrix
cellular response to oxidative stress
positive regulation of protein complex assembly
regulation of inflammatory response
extracellular matrix organization
extracellular structure organization
response to oxidative stress
cellular component disassembly
cellular response to drug
regulation of protein complex assembly