MMP9
Gene Information
- Official Symbol: MMP9
- Official Name: matrix metallopeptidase 9
- Aliases and Previous Symbols: N/A
- Entrez ID: 4318
- UniProt: P14780
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008].
- UniProt Summary: May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. {ECO:0000269|PubMed:1480034}.
Pfam Domains GO Terms
Pfam Domains
| Peptidase M10 |
| fn2 |
| Hemopexin |
| PG binding 1 |
| PT |
GO Terms
| negative regulation of epithelial cell differentiation involved in kidney development |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| positive regulation of receptor binding |
| positive regulation of keratinocyte migration |
| regulation of keratinocyte migration |
| negative regulation of kidney development |
| regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| regulation of epithelial cell differentiation involved in kidney development |
| regulation of receptor binding |
| macrophage differentiation |
| positive regulation of release of cytochrome c from mitochondria |
| regulation of neuroinflammatory response |
| positive regulation of epidermal growth factor receptor signaling pathway |
| positive regulation of vascular smooth muscle cell proliferation |
| positive regulation of ERBB signaling pathway |
| embryo implantation |
| cellular response to cadmium ion |
| endodermal cell differentiation |
| negative regulation of epithelial cell differentiation |
| collagen catabolic process |
| negative regulation of cation channel activity |
| endoderm formation |
| regulation of release of cytochrome c from mitochondria |
| response to amyloid-beta |
| regulation of vascular smooth muscle cell proliferation |
| tertiary granule lumen |
| regulation of kidney development |
| positive regulation of DNA binding |
| collagen binding |
| response to cadmium ion |
| metallopeptidase activity |
| collagen metabolic process |
| extracellular matrix disassembly |
| negative regulation of ion transmembrane transporter activity |
| endoderm development |
| endopeptidase activity |
| negative regulation of transporter activity |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| negative regulation of cation transmembrane transport |
| regulation of epidermal growth factor receptor signaling pathway |
| positive regulation of smooth muscle cell proliferation |
| ephrin receptor signaling pathway |
| negative regulation of cysteine-type endopeptidase activity |
| regulation of ERBB signaling pathway |
| positive regulation of protein binding |
| negative regulation of intrinsic apoptotic signaling pathway |
| negative regulation of ion transmembrane transport |
| metalloendopeptidase activity |
| myeloid leukocyte differentiation |
| formation of primary germ layer |
| positive regulation of mitochondrion organization |
| negative regulation of transmembrane transport |
| ficolin-1-rich granule lumen |
| regulation of DNA binding |
| cellular response to reactive oxygen species |
| regulation of smooth muscle cell proliferation |
| positive regulation of epithelial cell migration |
| regulation of epithelial cell differentiation |
| negative regulation of ion transport |
| gastrulation |
| regulation of intrinsic apoptotic signaling pathway |
| serine-type endopeptidase activity |
| regulation of cation channel activity |
| positive regulation of apoptotic signaling pathway |
| positive regulation of binding |
| regulation of mitochondrion organization |
| female pregnancy |
| cellular response to metal ion |
| response to reactive oxygen species |
| multi-multicellular organism process |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| regulation of protein binding |
| myeloid cell differentiation |
| cellular response to inorganic substance |
| regulation of epithelial cell migration |
| negative regulation of apoptotic signaling pathway |
| cellular response to oxidative stress |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of endopeptidase activity |
| negative regulation of peptidase activity |
| regulation of ion transmembrane transporter activity |
| regulation of transmembrane transporter activity |
| regulation of transporter activity |
| leukocyte differentiation |
| regulation of cation transmembrane transport |
| regulation of inflammatory response |
| extracellular matrix organization |
| negative regulation of proteolysis |
| collagen-containing extracellular matrix |
| response to metal ion |
| regulation of binding |
| extracellular structure organization |
| response to oxidative stress |
| regulation of apoptotic signaling pathway |
| cellular component disassembly |
| regulation of endopeptidase activity |
| regulation of peptidase activity |
| negative regulation of hydrolase activity |
| response to peptide |
| regulation of ion transmembrane transport |
| negative regulation of transport |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| skeletal system development |
| neutrophil mediated immunity |
| positive regulation of cell migration |
| neutrophil activation |
| granulocyte activation |
| negative regulation of intracellular signal transduction |
| leukocyte degranulation |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| myeloid leukocyte mediated immunity |
| positive regulation of cell motility |
| myeloid cell activation involved in immune response |
| response to inorganic substance |
| positive regulation of cellular component movement |
| positive regulation of locomotion |
| hemopoiesis |
| regulation of transmembrane transport |
| embryonic morphogenesis |
| myeloid leukocyte activation |
| hematopoietic or lymphoid organ development |
| positive regulation of organelle organization |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| positive regulation of apoptotic process |
| immune system development |
| positive regulation of programmed cell death |
| cytokine-mediated signaling pathway |
| positive regulation of cell death |
| regulation of ion transport |
| regulated exocytosis |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| regulation of proteolysis |
| regulation of defense response |
| leukocyte mediated immunity |
| negative regulation of catalytic activity |
| exocytosis |
| zinc ion binding |
| regulation of cell migration |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| leukocyte activation |
| negative regulation of developmental process |
| embryo development |
| regulation of locomotion |
| negative regulation of cell death |
| multi-organism reproductive process |
| regulation of cellular component movement |
| response to organonitrogen compound |
| secretion by cell |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| negative regulation of cellular protein metabolic process |
| export from cell |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| identical protein binding |
| cell activation |
| response to nitrogen compound |
| immune effector process |
| regulation of response to external stimulus |
| response to cytokine |
| negative regulation of protein metabolic process |
| secretion |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| proteolysis |
| regulation of hydrolase activity |
| regulation of organelle organization |
| negative regulation of cell communication |
| negative regulation of signaling |
| reproductive process |
| reproduction |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of apoptotic process |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of signal transduction |
| regulation of cell death |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| extracellular region |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| BI-2536 0.001μM R01 exp41 | 1.7 |
| 5-Fluorouracil 20μM R00 exp2 | 1.81 |
| Hydroxyurea 15μM R06 exp289 | 1.88 |
| BI-6727 0.04μM R03 exp98 | 1.91 |
| Oligomycin-A 20μM R00 exp26 | 1.97 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6182
- Expression level (log2 read counts): -1.33
Expression Distribution
MMP9 Expression in NALM6 Cells: -1.33
