MOB1B
Gene Information
- Official Symbol: MOB1B
- Official Name: MOB kinase activator 1B
- Aliases and Previous Symbols: N/A
- Entrez ID: 92597
- UniProt: Q7L9L4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L. {ECO:0000269|PubMed:15067004, ECO:0000269|PubMed:19739119}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 16416
- Expression level (log2 read counts): 5.95
MOB1B Expression in NALM6 Cells: 5.95
