MPP5

Entrez Summary: N/A
UniProt Summary: May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
UM131593 0.1μM R01 exp58	-2.24
Palbociclib 1μM R07 exp382	-1.7

protein localization to myelin sheath abaxonal region
lateral loop
myelin sheath adaxonal region
peripheral nervous system myelin maintenance
Schmidt-Lanterman incisure
myelin maintenance
myelin assembly
myelination in peripheral nervous system
peripheral nervous system axon ensheathment
Schwann cell development
establishment of epithelial cell polarity
Schwann cell differentiation
bicellular tight junction assembly
tight junction assembly
tight junction organization
apical junction assembly
morphogenesis of an epithelial sheet
peripheral nervous system development
endomembrane system
plasma membrane organization
cellular component assembly involved in morphogenesis
cell-cell junction assembly
cell-cell adherens junction
myelination
glial cell development
ensheathment of neurons
axon ensheathment
establishment of cell polarity
bicellular tight junction
cell-cell junction organization
cell junction assembly
glial cell differentiation
protein localization to plasma membrane
establishment or maintenance of cell polarity
cell junction organization
gliogenesis
protein localization to cell periphery
protein domain specific binding
endomembrane system organization
morphogenesis of an epithelium