MTMR2

Gene Information

Official Symbol: MTMR2
Official Name: myotubularin related protein 2
Aliases and Previous Symbols: N/A
Entrez ID: 8898
UniProt: Q13614
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene is a member of the myotubularin family of phosphoinositide lipid phosphatases. The encoded protein possesses phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4B, an autosomal recessive demyelinating neuropathy. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011].
UniProt Summary: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. {ECO:0000269|PubMed:11733541, ECO:0000269|PubMed:12668758, ECO:0000269|PubMed:21372139}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12853
Expression level (log2 read counts): 4.53

Expression Distribution

GRAM
Myotub-related

negative regulation of receptor catabolic process
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
regulation of phosphatidylinositol dephosphorylation
positive regulation of early endosome to late endosome transport
negative regulation of myelination
negative regulation of excitatory postsynaptic potential
regulation of receptor catabolic process
dendritic spine maintenance
phosphatidylinositol-3-phosphatase activity
negative regulation of receptor internalization
positive regulation of cytoplasmic transport
inositol phosphate dephosphorylation
phosphorylated carbohydrate dephosphorylation
inositol phosphate catabolic process
regulation of early endosome to late endosome transport
myelin assembly
phosphatidylinositol dephosphorylation
negative regulation of receptor-mediated endocytosis
regulation of cytoplasmic transport
negative regulation of nervous system process
polyol catabolic process
synaptic membrane
vacuolar membrane
dendritic spine organization
phospholipid dephosphorylation
modulation of excitatory postsynaptic potential
neuron projection organization
protein tyrosine/serine/threonine phosphatase activity
regulation of myelination
negative regulation of endocytosis
cellular component maintenance
regulation of receptor internalization
alcohol catabolic process
inositol phosphate metabolic process
negative regulation of synaptic transmission
organic hydroxy compound catabolic process
regulation of phospholipid metabolic process
postsynapse organization
protein tyrosine phosphatase activity
regulation of receptor-mediated endocytosis