MTMR8

Entrez Summary: This gene encodes a member of the myotubularin-related family and is part of the MTMR6 subgroup. Family members are dual-specificity phosphatases and the encoded protein contains a phosphoinositide-binding domain (PID) and a SET-interacting domain (SID). Defects in other family members have been found in myotubular myopathic diseases. [provided by RefSeq, Mar 2010].
UniProt Summary: Phosphatase that acts on lipids with a phosphoinositol headgroup. {ECO:0000305}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
phosphatidylinositol-3-phosphatase activity
phosphatidylinositol dephosphorylation
phospholipid dephosphorylation
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
phosphatidylinositol biosynthetic process
phosphatidylinositol metabolic process
nuclear envelope
lipid modification
glycerophospholipid biosynthetic process
protein dephosphorylation
glycerolipid biosynthetic process
phospholipid biosynthetic process
glycerophospholipid metabolic process
dephosphorylation
regulation of autophagy
phospholipid metabolic process
glycerolipid metabolic process
organophosphate biosynthetic process
lipid biosynthetic process
regulation of cellular catabolic process
organophosphate metabolic process
cellular lipid metabolic process
regulation of catabolic process
lipid metabolic process