MTNR1A

Entrez Summary: N/A
UniProt Summary: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

organic cyclic compound binding
melatonin receptor activity
hormone binding
mating behavior
reproductive behavior
mating
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
circadian rhythm
receptor complex
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
rhythmic process
behavior
G protein-coupled receptor activity
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
multi-organism reproductive process
G protein-coupled receptor signaling pathway
integral component of plasma membrane
reproductive process
reproduction