MUC7

Gene Information

Official Symbol: MUC7
Official Name: mucin 7, secreted
Aliases and Previous Symbols: N/A
Entrez ID: 4589
UniProt: Q8TAX7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a small salivary mucin, which is thought to play a role in facilitating the clearance of bacteria in the oral cavity and to aid in mastication, speech, and swallowing. The central domain of this glycoprotein contains tandem repeats, each composed of 23 amino acids. This antimicrobial protein has antibacterial and antifungal activity. The most common allele contains 6 repeats, and some alleles may be associated with susceptibility to asthma. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Oct 2014].
UniProt Summary: May function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili. {ECO:0000269|PubMed:11378823, ECO:0000269|PubMed:8104046}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17557
Expression level (log2 read counts): -7.68

Expression Distribution

Screen	Score
Nifuroxazide 1μM R01 exp51	1.85
A-395N 10μM R05 exp219	2.11

host cell cytoplasm
other organism cell membrane
disruption of cells of other organism
killing of cells of other organism
O-glycan processing
antimicrobial humoral immune response mediated by antimicrobial peptide
cell killing
Golgi lumen
protein O-linked glycosylation
antimicrobial humoral response
stimulatory C-type lectin receptor signaling pathway
innate immune response activating cell surface receptor signaling pathway
modification of morphology or physiology of other organism
innate immune response-activating signal transduction
activation of innate immune response
protein glycosylation
macromolecule glycosylation
glycosylation
glycoprotein biosynthetic process
positive regulation of innate immune response
humoral immune response
positive regulation of response to biotic stimulus
glycoprotein metabolic process
immune response-activating cell surface receptor signaling pathway
regulation of innate immune response
positive regulation of defense response
immune response-regulating cell surface receptor signaling pathway
positive regulation of multi-organism process
regulation of response to biotic stimulus
immune response-activating signal transduction
immune response-regulating signaling pathway
positive regulation of response to external stimulus
carbohydrate derivative biosynthetic process
activation of immune response
regulation of defense response
regulation of multi-organism process
interspecies interaction between organisms
positive regulation of immune response
carbohydrate derivative metabolic process
regulation of response to external stimulus