MUT

Entrez Summary: N/A
UniProt Summary: Involved in the degradation of several amino acids, odd- chain fatty acids and cholesterol via propionyl-CoA to the tricarboxylic acid cycle. MCM has different functions in other species.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

B12-binding
MM CoA mutase

methylmalonyl-CoA mutase activity
modified amino acid binding
short-chain fatty acid catabolic process
cobalamin binding
homocysteine metabolic process
short-chain fatty acid metabolic process
cobalamin metabolic process
sulfur amino acid metabolic process
tetrapyrrole metabolic process
water-soluble vitamin metabolic process
post-embryonic development
fatty acid catabolic process
monocarboxylic acid catabolic process
vitamin metabolic process
cellular lipid catabolic process
alpha-amino acid metabolic process
organic acid catabolic process
carboxylic acid catabolic process
lipid catabolic process
cellular amino acid metabolic process
fatty acid metabolic process
GTPase activity
sulfur compound metabolic process
mitochondrial matrix
positive regulation of GTPase activity
small molecule catabolic process
cofactor metabolic process
regulation of GTPase activity
drug metabolic process
monocarboxylic acid metabolic process
positive regulation of hydrolase activity
protein homodimerization activity
carboxylic acid metabolic process
cellular lipid metabolic process
oxoacid metabolic process
organic acid metabolic process
identical protein binding
lipid metabolic process
mitochondrion
regulation of hydrolase activity