MYH7

Entrez Summary: Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopathy, and Laing early-onset distal myopathy. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of slow-twitch skeletal muscle fiber contraction
regulation of the force of skeletal muscle contraction
regulation of skeletal muscle contraction by chemo-mechanical energy conversion
regulation of twitch skeletal muscle contraction
transition between fast and slow fiber
actin-dependent ATPase activity
regulation of skeletal muscle contraction
muscle hypertrophy in response to stress
cardiac muscle hypertrophy in response to stress
cardiac muscle adaptation
adult heart development
muscle myosin complex
regulation of skeletal muscle adaptation
myosin filament
microfilament motor activity
regulation of the force of heart contraction
striated muscle adaptation
myofibril
cardiac muscle hypertrophy
skeletal muscle contraction
striated muscle hypertrophy
muscle hypertrophy
muscle adaptation
myosin complex
muscle filament sliding
actin-myosin filament sliding
musculoskeletal movement
multicellular organismal movement
ventricular cardiac muscle tissue morphogenesis
sarcomere
ventricular cardiac muscle tissue development
cardiac muscle tissue morphogenesis
stress fiber
cardiac ventricle morphogenesis
cardiac muscle contraction
muscle tissue morphogenesis
regulation of muscle adaptation
muscle organ morphogenesis
heart contraction
actin-mediated cell contraction