MYL4

Entrez Summary: Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: Regulatory light chain of myosin. Does not bind calcium.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

myosin II heavy chain binding
A band
regulation of the force of heart contraction
actin monomer binding
myosin complex
muscle filament sliding
actin-myosin filament sliding
positive regulation of ATPase activity
cardiac muscle contraction
regulation of ATPase activity
heart contraction
actin-mediated cell contraction
heart process
striated muscle contraction
actin filament-based movement
actin filament binding
regulation of heart contraction
muscle contraction
regulation of blood circulation
muscle system process
blood circulation
circulatory system process
actin filament-based process
regulation of system process
calcium ion binding
positive regulation of hydrolase activity
regulation of hydrolase activity
positive regulation of catalytic activity
movement of cell or subcellular component
positive regulation of molecular function
system process