MYLIP

Gene Information

Official Symbol: MYLIP
Official Name: myosin regulatory light chain interacting protein
Aliases and Previous Symbols: N/A
Entrez ID: 29116
UniProt: Q8WY64
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol- dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. {ECO:0000269|PubMed:10593918, ECO:0000269|PubMed:12826659, ECO:0000269|PubMed:14550572, ECO:0000269|PubMed:19520913, ECO:0000269|PubMed:20427281, ECO:0000269|PubMed:22109552}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cerivastatin 0.15μM R05 exp226	-2.44
TIC10 10μM R08 exp532	-2.31
Palbociclib 1μM R07 exp382	-1.94
6-Thio-2-deoxyguanosine 2μM R06 exp259	-1.83
CCCP 1μM R00 exp11	1.93
LB-100 2μM R05 exp210	1.96
Bortezomib 0.05μM R00 exp7	1.98
Dynasore 7μM R08 exp436	2.72

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4334
Expression level (log2 read counts): 4.08

Expression Distribution

FERM M
FERM N

negative regulation of low-density lipoprotein particle clearance
regulation of low-density lipoprotein particle receptor catabolic process
negative regulation of lipoprotein particle clearance
low-density lipoprotein particle receptor catabolic process
regulation of receptor catabolic process
low-density lipoprotein receptor particle metabolic process
regulation of low-density lipoprotein particle clearance
regulation of lipoprotein particle clearance
receptor catabolic process
protein destabilization
cytoskeletal protein binding
cholesterol homeostasis
sterol homeostasis
receptor metabolic process
lipid homeostasis
negative regulation of neuron projection development
negative regulation of cell projection organization
positive regulation of protein catabolic process
ubiquitin protein ligase activity
negative regulation of neuron differentiation
ubiquitin-protein transferase activity
regulation of cellular protein catabolic process
regulation of protein stability
negative regulation of neurogenesis
protein polyubiquitination
negative regulation of nervous system development
negative regulation of cell development
cytoskeleton
regulation of protein catabolic process
positive regulation of catabolic process
regulation of neuron projection development
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
regulation of neuron differentiation
protein catabolic process
protein ubiquitination
regulation of plasma membrane bounded cell projection organization