NAGK

Entrez Summary: N/A
UniProt Summary: Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Also has ManNAc kinase activity. {ECO:0000269|PubMed:22692205}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

N-acetylglucosamine kinase activity
mannosamine metabolic process
N-acetylmannosamine metabolic process
N-acetylneuraminate catabolic process
UDP-N-acetylglucosamine biosynthetic process
N-acetylneuraminate metabolic process
amino sugar catabolic process
amino sugar biosynthetic process
UDP-N-acetylglucosamine metabolic process
N-acetylglucosamine metabolic process
nucleotide-sugar biosynthetic process
carbohydrate phosphorylation
glucosamine-containing compound metabolic process
nucleotide-sugar metabolic process
amino sugar metabolic process
antibiotic catabolic process
antibiotic metabolic process
drug catabolic process
cellular carbohydrate metabolic process
carbohydrate derivative catabolic process
carboxylic acid catabolic process
organic acid catabolic process
small molecule catabolic process
carbohydrate metabolic process
drug metabolic process
nucleobase-containing small molecule metabolic process
carbohydrate derivative biosynthetic process
carboxylic acid metabolic process
oxoacid metabolic process
organic acid metabolic process
carbohydrate derivative metabolic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
phosphorylation
organic cyclic compound biosynthetic process
ATP binding
cellular nitrogen compound biosynthetic process
small molecule metabolic process
organic substance catabolic process