NARG2

Entrez Summary: This gene encodes a protein component of the little elongation complex (LEC), which plays a role in small nuclear RNA (snRNA) transcription. The LEC regulates snRNA transcription by enhancing both RNA Polymerase II occupancy and transcriptional elongation. The encoded protein and other LEC components have been shown to localize to Cajal bodies, which are sites of ribonucleoprotein (RNP) complex assembly. Pseudogenes of this gene have been identified on chromosomes 3 and 4. [provided by RefSeq, May 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 133/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	7/28
blood	1/28
bone	2/26
breast	8/33
central nervous system	12/56
cervix	0/4
colorectal	2/17
esophagus	5/13
fibroblast	0/1
gastric	0/16
kidney	5/21
liver	4/20
lung	19/75
lymphocyte	1/16
ovary	7/26
pancreas	6/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	2/24
soft tissue	3/9
thyroid	0/2
upper aerodigestive	4/22
urinary tract	8/29
uterus	2/5

Expression Distribution

histone locus body
snRNA transcription by RNA polymerase III
positive regulation of transcription by RNA polymerase III
regulation of transcription by RNA polymerase III
transcriptionally active chromatin
transcription elongation factor complex
transcription by RNA polymerase III
Cajal body
snRNA transcription by RNA polymerase II
snRNA transcription
ncRNA transcription
nuclear body
transcription by RNA polymerase II
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
organic cyclic compound biosynthetic process
positive regulation of transcription, DNA-templated
cellular nitrogen compound biosynthetic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process
cellular macromolecule biosynthetic process
positive regulation of RNA metabolic process
macromolecule biosynthetic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
gene expression
positive regulation of biosynthetic process