NEK4

Entrez Summary: The protein encoded by this gene is a serine/threonine protein kinase required for normal entry into replicative senescence. The encoded protein also is involved in cell cycle arrest in response to double-stranded DNA damage. Finally, this protein plays a role in maintaining cilium integrity, and defects in this gene have been associated with ciliopathies. [provided by RefSeq, Jan 2017].
UniProt Summary: Protein kinase that seems to act exclusively upon threonine residues (By similarity). Required for normal entry into proliferative arrest after a limited number of cell divisions, also called replicative senescence. Required for normal cell cycle arrest in response to double-stranded DNA damage. {ECO:0000250|UniProtKB:Q9Z1J2, ECO:0000269|PubMed:22851694}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	1/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Pkinase
Pkinase Tyr

regulation of replicative cell aging
ciliary plasm
ciliary rootlet
ciliary transition zone
regulation of cellular senescence
regulation of cell aging
manganese ion binding
ciliary basal body
stress-activated protein kinase signaling cascade
regulation of response to DNA damage stimulus
activation of protein kinase activity
protein serine/threonine kinase activity
signal transduction by protein phosphorylation
cell division
positive regulation of protein kinase activity
positive regulation of kinase activity
positive regulation of transferase activity
mitotic cell cycle
regulation of cellular response to stress
cellular response to DNA damage stimulus
regulation of protein kinase activity
regulation of kinase activity
protein phosphorylation
regulation of transferase activity
positive regulation of protein phosphorylation
positive regulation of phosphorylation
positive regulation of phosphorus metabolic process
positive regulation of phosphate metabolic process
positive regulation of protein modification process
phosphorylation
cell cycle
positive regulation of catalytic activity
regulation of protein phosphorylation
regulation of response to stress
ATP binding
positive regulation of transcription, DNA-templated
regulation of phosphorylation
positive regulation of cellular protein metabolic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process