NEUROG1
Gene Information
- Official Symbol: NEUROG1
- Official Name: neurogenin 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 4762
- UniProt: Q92886
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Acts as a transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| HLH |
GO Terms
| hard palate morphogenesis |
| mastication |
| negative regulation of saliva secretion |
| learned vocalization behavior |
| negative regulation of relaxation of muscle |
| vestibulocochlear nerve formation |
| thorax and anterior abdomen determination |
| positive regulation of exit from mitosis |
| zygotic determination of anterior/posterior axis, embryo |
| vestibulocochlear nerve morphogenesis |
| regulation of saliva secretion |
| cranial nerve formation |
| peristalsis |
| vestibulocochlear nerve development |
| learned vocalization behavior or vocal learning |
| regulation of relaxation of muscle |
| trigeminal nerve development |
| auditory behavior |
| genitalia morphogenesis |
| sequence-specific double-stranded DNA binding |
| mechanosensory behavior |
| anterior/posterior axis specification, embryo |
| tripartite regional subdivision |
| vocalization behavior |
| craniofacial suture morphogenesis |
| phasic smooth muscle contraction |
| blastoderm segmentation |
| negative regulation of digestive system process |
| regulation of exit from mitosis |
| cochlea morphogenesis |
| response to auditory stimulus |
| cranial nerve morphogenesis |
| embryonic axis specification |
| regulation of digestive system process |
| genitalia development |
| anterior/posterior axis specification |
| E-box binding |
| cochlea development |
| cranial nerve development |
| neuromuscular process controlling balance |
| smooth muscle contraction |
| positive regulation of mitotic nuclear division |
| embryonic pattern specification |
| positive regulation of nuclear division |
| cranial skeletal system development |
| digestive system process |
| positive regulation of mitotic cell cycle phase transition |
| nerve development |
| axis specification |
| positive regulation of cell cycle phase transition |
| segmentation |
| inner ear morphogenesis |
| neuromuscular process |
| digestion |
| bone morphogenesis |
| ear morphogenesis |
| perikaryon |
| regulation of muscle organ development |
| positive regulation of mitotic cell cycle |
| regulation of mitotic nuclear division |
| regulation of nuclear division |
| inner ear development |
| bone development |
| response to mechanical stimulus |
| anterior/posterior pattern specification |
| ear development |
| negative regulation of secretion |
| regulation of muscle system process |
| skeletal system morphogenesis |
| cell fate commitment |
| muscle contraction |
| sensory organ morphogenesis |
| learning or memory |
| positive regulation of DNA-binding transcription factor activity |
| sex differentiation |
| positive regulation of cell cycle process |
| embryonic organ morphogenesis |
| cognition |
| muscle system process |
| regionalization |
| positive regulation of neuron differentiation |
| positive regulation of cell cycle |
| chromatin binding |
| regulation of mitotic cell cycle phase transition |
| reproductive structure development |
| regulation of DNA-binding transcription factor activity |
| reproductive system development |
| embryonic organ development |
| pattern specification process |
| regulation of cell cycle phase transition |
| positive regulation of neurogenesis |
| negative regulation of transport |
| skeletal system development |
| regulation of body fluid levels |
| positive regulation of nervous system development |
| positive regulation of cell development |
| sensory organ development |
| embryonic morphogenesis |
| behavior |
| regulation of system process |
| positive regulation of organelle organization |
| regulation of mitotic cell cycle |
| regulation of neuron differentiation |
| developmental process involved in reproduction |
| DNA-binding transcription factor activity |
| regulation of cell cycle process |
| regulation of secretion |
| regulation of neurogenesis |
| protein homodimerization activity |
| anatomical structure formation involved in morphogenesis |
| regulation of nervous system development |
| regulation of cell development |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| embryo development |
| neuron differentiation |
| response to abiotic stimulus |
| regulation of cell cycle |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| regulation of organelle organization |
| positive regulation of developmental process |
| nervous system process |
| reproductive process |
| reproduction |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of cell differentiation |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| BI-2536 0.001μM R01 exp41 | -2.28 |
| LJH685 5μM R02 exp73 | -1.74 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5428
- Expression level (log2 read counts): -7.68
Expression Distribution
NEUROG1 Expression in NALM6 Cells: -7.68
