NFKBIL1

Gene Information

Official Symbol: NFKBIL1
Official Name: NFKB inhibitor like 1
Aliases and Previous Symbols: N/A
Entrez ID: 4795
UniProt: Q9UBC1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11395
Expression level (log2 read counts): 2.7

Expression Distribution

Screen	Score
NFN1 0.4μM R03 exp99	-1.8
Doxorubicin 0.02μM R08 exp478	-1.73
Nocodazole 0.2μM R02 exp64	1.95

negative regulation of lipopolysaccharide-mediated signaling pathway
cytoplasmic sequestering of transcription factor
cytoplasmic sequestering of protein
regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of toll-like receptor signaling pathway
negative regulation of tumor necrosis factor production
negative regulation of tumor necrosis factor superfamily cytokine production
regulation of toll-like receptor signaling pathway
I-kappaB kinase/NF-kappaB signaling
negative regulation of NF-kappaB transcription factor activity
negative regulation of response to biotic stimulus
maintenance of protein location
regulation of tumor necrosis factor production
regulation of tumor necrosis factor superfamily cytokine production
negative regulation of DNA-binding transcription factor activity
maintenance of location
cellular response to lipopolysaccharide
cellular response to molecule of bacterial origin
negative regulation of multi-organism process
cellular response to biotic stimulus
negative regulation of cytokine production
response to lipopolysaccharide
response to molecule of bacterial origin
negative regulation of response to external stimulus
regulation of DNA-binding transcription factor activity
negative regulation of immune system process
regulation of innate immune response
cellular response to lipid
regulation of response to biotic stimulus
response to bacterium
regulation of cytokine production
regulation of defense response
regulation of multi-organism process
response to lipid
cellular response to oxygen-containing compound
regulation of response to external stimulus
negative regulation of molecular function
regulation of immune response
negative regulation of multicellular organismal process
negative regulation of signal transduction