NINL

Entrez Summary: N/A
UniProt Summary: Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. May play a role in ovarian carcinogenesis. {ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:16254247, ECO:0000269|PubMed:18538832}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

microtubule anchoring at centrosome
microtubule anchoring at microtubule organizing center
microtubule anchoring
intercellular bridge
ciliary basal body-plasma membrane docking
G2/M transition of mitotic cell cycle
cell cycle G2/M phase transition
organelle localization by membrane tethering
membrane docking
regulation of G2/M transition of mitotic cell cycle
regulation of cell cycle G2/M phase transition
mitotic cell cycle phase transition
cell cycle phase transition
microtubule
cilium assembly
cilium organization
regulation of mitotic cell cycle phase transition
plasma membrane bounded cell projection assembly
regulation of cell cycle phase transition
cell projection assembly
microtubule cytoskeleton organization
centrosome
organelle localization
mitotic cell cycle process
regulation of mitotic cell cycle
microtubule-based process
mitotic cell cycle
calcium ion binding
regulation of cell cycle process
organelle assembly
cell cycle process
cytoskeleton organization
plasma membrane bounded cell projection organization
cell projection organization
regulation of cell cycle
cell cycle