NIT2

Entrez Summary: N/A
UniProt Summary: Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha- ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively. Overexpression decreases the colony-forming capacity of cultured cells by arresting cells in the G2 phase of the cell cycle. {ECO:0000269|PubMed:17488281, ECO:0000269|PubMed:19595734}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Etoposide 10μM R00 exp20	-1.77
Dimethyloxaloylglycine 100μM R05 exp229	7.77

Gene	Correlation
POLR2J3	0.47
HIF1A	0.419

omega-amidase activity
asparagine metabolic process
oxaloacetate metabolic process
glutamine metabolic process
aspartate family amino acid metabolic process
tertiary granule lumen
specific granule lumen
glutamine family amino acid metabolic process
dicarboxylic acid metabolic process
alpha-amino acid metabolic process
cellular amino acid metabolic process
neutrophil degranulation
centrosome
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
monocarboxylic acid metabolic process
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
regulated exocytosis
leukocyte mediated immunity
cellular amide metabolic process
exocytosis
carboxylic acid metabolic process
leukocyte activation
oxoacid metabolic process
secretion by cell
organic acid metabolic process
export from cell
cell activation
immune effector process
secretion
small molecule metabolic process
immune response
extracellular region