NKIRAS2

Gene Information
  • Official Symbol: NKIRAS2
  • Official Name: NFKB inhibitor interacting Ras like 2
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 28511
  • UniProt: Q9NYR9
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: N/A
  • UniProt Summary: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF- kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity). {ECO:0000250}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 11013
  • Expression level (log2 read counts): 5.86

Expression Distribution

  • Last modified: 2026/01/07 22:36
  • by 127.0.0.1