NME5
Gene Information
- Official Symbol: NME5
- Official Name: NME/NM23 family member 5
- Aliases and Previous Symbols: N/A
- Entrez ID: 8382
- UniProt: P56597
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Does not seem to have NDK kinase activity. Confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes including Gpx5. May play a role in spermiogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species (By similarity). {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| NDK |
| Dpy-30 |
GO Terms
| UTP biosynthetic process |
| GTP biosynthetic process |
| UTP metabolic process |
| CTP metabolic process |
| guanosine-containing compound biosynthetic process |
| CTP biosynthetic process |
| pyrimidine ribonucleoside triphosphate biosynthetic process |
| pyrimidine ribonucleoside triphosphate metabolic process |
| negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| pyrimidine nucleoside triphosphate biosynthetic process |
| nucleoside diphosphate kinase activity |
| pyrimidine ribonucleotide biosynthetic process |
| ribonucleoside biosynthetic process |
| purine ribonucleoside biosynthetic process |
| pyrimidine nucleoside triphosphate metabolic process |
| purine nucleoside biosynthetic process |
| pyrimidine ribonucleotide metabolic process |
| GTP metabolic process |
| ventricular system development |
| epithelial cilium movement involved in extracellular fluid movement |
| regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| extracellular transport |
| nucleoside biosynthetic process |
| guanosine-containing compound metabolic process |
| glycosyl compound biosynthetic process |
| sperm flagellum |
| negative regulation of oxidative stress-induced cell death |
| purine ribonucleoside triphosphate biosynthetic process |
| negative regulation of cellular response to oxidative stress |
| purine nucleoside triphosphate biosynthetic process |
| pyrimidine nucleotide biosynthetic process |
| negative regulation of response to oxidative stress |
| ribonucleoside triphosphate biosynthetic process |
| pyrimidine-containing compound biosynthetic process |
| purine ribonucleoside triphosphate metabolic process |
| cilium movement |
| nucleoside diphosphate phosphorylation |
| purine ribonucleoside metabolic process |
| nucleotide phosphorylation |
| pyrimidine nucleotide metabolic process |
| nucleoside triphosphate biosynthetic process |
| regulation of oxidative stress-induced cell death |
| purine nucleoside metabolic process |
| ribonucleoside triphosphate metabolic process |
| purine nucleoside triphosphate metabolic process |
| regulation of cellular response to oxidative stress |
| ribonucleoside metabolic process |
| nucleoside diphosphate metabolic process |
| regulation of response to oxidative stress |
| nucleoside triphosphate metabolic process |
| negative regulation of intrinsic apoptotic signaling pathway |
| pyrimidine-containing compound metabolic process |
| nucleobase-containing small molecule biosynthetic process |
| nucleoside metabolic process |
| glycosyl compound metabolic process |
| purine ribonucleotide biosynthetic process |
| spermatid development |
| purine nucleotide biosynthetic process |
| spermatid differentiation |
| regulation of intrinsic apoptotic signaling pathway |
| ribonucleotide biosynthetic process |
| ribose phosphate biosynthetic process |
| purine-containing compound biosynthetic process |
| microtubule-based transport |
| negative regulation of apoptotic signaling pathway |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| germ cell development |
| microtubule-based movement |
| purine ribonucleotide metabolic process |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| cilium assembly |
| cellular process involved in reproduction in multicellular organism |
| purine-containing compound metabolic process |
| cilium organization |
| regulation of apoptotic signaling pathway |
| nucleotide metabolic process |
| plasma membrane bounded cell projection assembly |
| cellular component |
| nucleoside phosphate metabolic process |
| cell projection assembly |
| negative regulation of intracellular signal transduction |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| spermatogenesis |
| male gamete generation |
| small molecule biosynthetic process |
| carbohydrate derivative biosynthetic process |
| developmental process involved in reproduction |
| microtubule-based process |
| gamete generation |
| regulation of cellular response to stress |
| brain development |
| organelle assembly |
| head development |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| organophosphate metabolic process |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| central nervous system development |
| negative regulation of cell death |
| multi-organism reproductive process |
| carbohydrate derivative metabolic process |
| nucleobase-containing compound biosynthetic process |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of signal transduction |
| phosphorylation |
| organic cyclic compound biosynthetic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| organonitrogen compound biosynthetic process |
| reproductive process |
| reproduction |
| regulation of response to stress |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| regulation of programmed cell death |
| negative regulation of response to stimulus |
| cellular nitrogen compound biosynthetic process |
| cell development |
| regulation of cell death |
| small molecule metabolic process |
| regulation of intracellular signal transduction |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| 4-Nitroquinoline-1-oxide 0.5μM R08 exp446 | -2.02 |
| 2-Deoxy-D-glucose 800μM R05 exp214 | 1.77 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16253
- Expression level (log2 read counts): -1.72
Expression Distribution
NME5 Expression in NALM6 Cells: -1.72
