NMRAL1

Gene Information

Official Symbol: NMRAL1
Official Name: NmrA like redox sensor 1
Aliases and Previous Symbols: N/A
Entrez ID: 57407
UniProt: Q9HBL8
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer. {ECO:0000269|PubMed:17496144, ECO:0000269|PubMed:18263583, ECO:0000269|PubMed:19254724}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6205
Expression level (log2 read counts): 5.02

Expression Distribution

Screen	Score
Vinblastine 0.2μM R03 exp108	-2.56
GSK-J4 1μM R07 exp362	-1.75
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	4.9

nitrogen catabolite repression of transcription
catabolite repression
nitrogen catabolite repression of transcription from RNA polymerase II promoter
nitrogen catabolite regulation of transcription from RNA polymerase II promoter
nitrogen catabolite regulation of transcription
regulation of nitrogen utilization
urea cycle
urea metabolic process
nitrogen cycle metabolic process
cellular response to nutrient
response to nutrient
cellular response to nutrient levels
cellular response to extracellular stimulus
cellular response to external stimulus
response to nutrient levels
amide biosynthetic process
response to extracellular stimulus
cellular response to organonitrogen compound
cellular response to nitrogen compound
perinuclear region of cytoplasm
cellular amide metabolic process
response to organonitrogen compound
identical protein binding
response to nitrogen compound
negative regulation of transcription, DNA-templated
cellular response to endogenous stimulus
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
organonitrogen compound biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
response to endogenous stimulus
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
cellular nitrogen compound biosynthetic process
negative regulation of gene expression
small molecule metabolic process