NMRK2

Entrez Summary: N/A
UniProt Summary: Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis. {ECO:0000269|PubMed:10613898, ECO:0000269|PubMed:15137942}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ribosylnicotinate kinase activity
ribosylnicotinamide kinase activity
negative regulation of myoblast differentiation
NAD biosynthetic process
nicotinamide nucleotide biosynthetic process
pyridine nucleotide biosynthetic process
pyridine nucleotide metabolic process
nicotinamide nucleotide metabolic process
pyridine-containing compound biosynthetic process
pyridine-containing compound metabolic process
NAD metabolic process
oxidoreduction coenzyme metabolic process
regulation of myoblast differentiation
coenzyme biosynthetic process
cofactor biosynthetic process
nucleotide biosynthetic process
nucleoside phosphate biosynthetic process
coenzyme metabolic process
cofactor metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
organophosphate biosynthetic process
nucleobase-containing small molecule metabolic process
intracellular membrane-bounded organelle
negative regulation of cell differentiation
organophosphate metabolic process
negative regulation of developmental process
nucleobase-containing compound biosynthetic process
heterocycle biosynthetic process
aromatic compound biosynthetic process
phosphorylation
organic cyclic compound biosynthetic process
organonitrogen compound biosynthetic process
ATP binding
cellular nitrogen compound biosynthetic process
small molecule metabolic process
regulation of cell differentiation