NMUR2
Gene Information
- Official Symbol: NMUR2
- Official Name: neuromedin U receptor 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 56923
- UniProt: Q9GZQ4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Receptor for the neuromedin-U and neuromedin-S neuropeptides. {ECO:0000250, ECO:0000269|PubMed:10899166}.
Pfam Domains GO Terms
Pfam Domains
| 7TM GPCR Srsx |
| 7tm 1 |
GO Terms
| neuromedin U binding |
| neuromedin U receptor activity |
| activation of phospholipase A2 activity by calcium-mediated signaling |
| activation of phospholipase A2 activity |
| reduction of food intake in response to dietary excess |
| positive regulation of phospholipase A2 activity |
| regulation of phospholipase A2 activity |
| grooming behavior |
| intracellular calcium activated chloride channel activity |
| inositol phosphate-mediated signaling |
| arachidonate transport |
| arachidonic acid secretion |
| response to dietary excess |
| icosanoid secretion |
| eating behavior |
| response to pain |
| icosanoid transport |
| fatty acid derivative transport |
| regulation of sensory perception of pain |
| regulation of sensory perception |
| long-chain fatty acid transport |
| positive regulation of phospholipase activity |
| regulation of smooth muscle contraction |
| multicellular organismal response to stress |
| regulation of phospholipase activity |
| positive regulation of lipase activity |
| fatty acid transport |
| acid secretion |
| feeding behavior |
| phospholipase C-activating G protein-coupled receptor signaling pathway |
| regulation of lipase activity |
| neuropeptide signaling pathway |
| regulation of nervous system process |
| monocarboxylic acid transport |
| calcium-mediated signaling |
| regulation of muscle contraction |
| regulation of muscle system process |
| calcium ion transport |
| positive regulation of cytosolic calcium ion concentration |
| carboxylic acid transport |
| organic acid transport |
| divalent metal ion transport |
| lipid transport |
| divalent inorganic cation transport |
| lipid localization |
| regulation of cytosolic calcium ion concentration |
| second-messenger-mediated signaling |
| GTP binding |
| cellular calcium ion homeostasis |
| calcium ion homeostasis |
| organic anion transport |
| cellular divalent inorganic cation homeostasis |
| divalent inorganic cation homeostasis |
| response to nutrient levels |
| response to extracellular stimulus |
| cellular metal ion homeostasis |
| behavior |
| anion transport |
| regulation of system process |
| metal ion homeostasis |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| cation homeostasis |
| inorganic ion homeostasis |
| G protein-coupled receptor activity |
| cellular chemical homeostasis |
| positive regulation of hydrolase activity |
| ion homeostasis |
| cation transport |
| cellular homeostasis |
| ion transmembrane transport |
| central nervous system development |
| chemical homeostasis |
| cell-cell signaling |
| secretion |
| transmembrane transport |
| regulation of hydrolase activity |
| G protein-coupled receptor signaling pathway |
| ion transport |
| positive regulation of catalytic activity |
| homeostatic process |
| intracellular signal transduction |
| positive regulation of molecular function |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| CCCP 1μM R00 exp11 | -1.82 |
| Asunaprenir 3μM R07 exp336 | -1.73 |
| Nicotinamide Riboside 100μM R03 exp139 | -1.71 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 8712
- Expression level (log2 read counts): -1.11
Expression Distribution
NMUR2 Expression in NALM6 Cells: -1.11
