NNT

Entrez Summary: This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. [provided by RefSeq, Sep 2016].
UniProt Summary: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. May play a role in reactive oxygen species (ROS) detoxification in the adrenal gland. {ECO:0000269|PubMed:22634753}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
QNZ 0.01μM R05 exp241	-2.83
Amiloride 100μM R08 exp447	-2.17
Milciclib 2μM R08 exp502	-1.88
Hinokiflavone 12μM R08 exp487	-1.83
Phenformin 20μM R03 exp143	-1.79
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-1.77
Phenformin 20μM R05 exp212	-1.75
BH1 1μM R04 exp169	-1.74
Cisplatin 0.35μM R06 exp273	1.79
Dimethyl-Sulfoxide 1pc R03 exp120	1.8
Oligomycin-A 2μM R00 exp25	2.43

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

NAD(P)+ transhydrogenase (B-specific) activity
NAD(P)+ transhydrogenase activity
positive regulation of hydrogen peroxide catabolic process
regulation of hydrogen peroxide catabolic process
positive regulation of hydrogen peroxide metabolic process
oxygen homeostasis
positive regulation of cofactor metabolic process
positive regulation of mitochondrial membrane potential
gas homeostasis
mitochondrial respirasome
NADPH regeneration
positive regulation of membrane potential
regulation of hydrogen peroxide metabolic process
NADP metabolic process
tricarboxylic acid cycle
regulation of cofactor metabolic process
NADP binding
NAD binding
regulation of mitochondrial membrane potential
cell redox homeostasis
aerobic respiration
response to vitamin
cellular oxidant detoxification
positive regulation of reactive oxygen species metabolic process
cellular detoxification
reactive oxygen species metabolic process
detoxification
proton transmembrane transport
cellular respiration
regulation of reactive oxygen species metabolic process
cellular response to toxic substance
response to nutrient
energy derivation by oxidation of organic compounds
positive regulation of cellular catabolic process
mitochondrial inner membrane
monovalent inorganic cation transport
negative regulation of protein phosphorylation
generation of precursor metabolites and energy
regulation of membrane potential
positive regulation of catabolic process