NOL11

Entrez Summary: N/A
UniProt Summary: Ribosome biogenesis factor. May be required for both optimal rDNA transcription and small subunit (SSU) pre-rRNA processing at sites A', A0, 1 and 2b. {ECO:0000269|PubMed:22916032}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Rotenone 20μM R00 exp34	-2.28
RK-33 8μM R08 exp518	-2.16
S-DABN 8μM R03 exp112	-1.85
Dinaciclib 0.007μM R07 exp355	-1.76
Hypoxia 5%O2 R04 exp191	-1.72
Dimethyloxaloylglycine 100μM R05 exp229	1.71
Ibrutinib 1μM R07 exp372	1.71
Tunicamycin 0.04μM R07 exp418	1.72

Global Fraction of Cell Lines Where Essential: 6/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	1/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	1/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

t-UTP complex
positive regulation of transcription of nucleolar large rRNA by RNA polymerase I
regulation of transcription of nucleolar large rRNA by RNA polymerase I
positive regulation of transcription by RNA polymerase I
regulation of transcription by RNA polymerase I
maturation of SSU-rRNA
ribosomal small subunit biogenesis
rRNA processing
rRNA metabolic process
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
nucleolus
RNA processing
RNA binding
positive regulation of transcription, DNA-templated
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
RNA metabolic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
gene expression
positive regulation of biosynthetic process