NOS2
Gene Information
- Official Symbol: NOS2
- Official Name: nitric oxide synthase 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 4843
- UniProt: P35228
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Flavodoxin 1 |
| NO synthase |
| NAD binding 1 |
| FAD binding 1 |
GO Terms
| nitric-oxide synthase activity |
| prostaglandin secretion |
| tetrahydrobiopterin binding |
| interleukin-8 secretion |
| interleukin-6 secretion |
| protein nitrosylation |
| NADPH-hemoprotein reductase activity |
| prostaglandin transport |
| peptidyl-cysteine S-nitrosylation |
| interleukin-8 production |
| arginine binding |
| arginine catabolic process |
| positive regulation of guanylate cyclase activity |
| interleukin-6 production |
| regulation of guanylate cyclase activity |
| nitric oxide biosynthetic process |
| positive regulation of killing of cells of other organism |
| FMN binding |
| nitric oxide metabolic process |
| regulation of killing of cells of other organism |
| arginine metabolic process |
| cortical cytoskeleton |
| innate immune response in mucosa |
| reactive nitrogen species metabolic process |
| nitric oxide mediated signal transduction |
| positive regulation of nucleotide biosynthetic process |
| positive regulation of purine nucleotide biosynthetic process |
| positive regulation of cyclase activity |
| positive regulation of lyase activity |
| reactive oxygen species biosynthetic process |
| glutamine family amino acid catabolic process |
| icosanoid secretion |
| vesicle membrane |
| mucosal immune response |
| regulation of cellular respiration |
| fatty acid derivative transport |
| icosanoid transport |
| organ or tissue specific immune response |
| NADP binding |
| peptidyl-cysteine modification |
| regulation of purine nucleotide biosynthetic process |
| superoxide metabolic process |
| regulation of nucleotide biosynthetic process |
| regulation of cytokine production involved in inflammatory response |
| regulation of cyclase activity |
| neurotransmitter biosynthetic process |
| positive regulation of nucleotide metabolic process |
| negative regulation of blood pressure |
| regulation of lyase activity |
| positive regulation of purine nucleotide metabolic process |
| cytokine secretion |
| peroxisomal matrix |
| positive regulation of leukocyte mediated cytotoxicity |
| flavin adenine dinucleotide binding |
| positive regulation of cell killing |
| protein localization to peroxisome |
| protein targeting to peroxisome |
| establishment of protein localization to peroxisome |
| glutamine family amino acid metabolic process |
| peroxisomal transport |
| fatty acid transport |
| cell redox homeostasis |
| regulation of leukocyte mediated cytotoxicity |
| peroxisome organization |
| acid secretion |
| defense response to Gram-negative bacterium |
| neurotransmitter metabolic process |
| regulation of cell killing |
| alpha-amino acid catabolic process |
| peroxisome |
| reactive oxygen species metabolic process |
| regulation of purine nucleotide metabolic process |
| regulation of nucleotide metabolic process |
| oxidoreductase activity |
| cellular amino acid catabolic process |
| negative regulation of protein catabolic process |
| monocarboxylic acid transport |
| positive regulation of small molecule metabolic process |
| circadian rhythm |
| heme binding |
| cytokine production |
| protein secretion |
| establishment of protein localization to extracellular region |
| regulation of generation of precursor metabolites and energy |
| cellular response to interferon-gamma |
| protein localization to extracellular region |
| peptide secretion |
| regulation of insulin secretion |
| response to interferon-gamma |
| regulation of blood pressure |
| cellular response to lipopolysaccharide |
| cellular response to molecule of bacterial origin |
| calmodulin binding |
| alpha-amino acid metabolic process |
| regulation of peptide hormone secretion |
| cellular response to biotic stimulus |
| carboxylic acid catabolic process |
| organic acid catabolic process |
| regulation of hormone secretion |
| rhythmic process |
| organic acid transport |
| carboxylic acid transport |
| lipid transport |
| negative regulation of catabolic process |
| cellular amino acid metabolic process |
| response to lipopolysaccharide |
| lipid localization |
| response to molecule of bacterial origin |
| defense response to bacterium |
| regulation of inflammatory response |
| second-messenger-mediated signaling |
| response to hypoxia |
| regulation of neurotransmitter levels |
| response to decreased oxygen levels |
| protein targeting |
| response to oxygen levels |
| regulation of protein catabolic process |
| blood circulation |
| circulatory system process |
| cellular response to drug |
| regulation of small molecule metabolic process |
| establishment of protein localization to organelle |
| small molecule catabolic process |
| organic anion transport |
| regulation of protein secretion |
| regulation of peptide secretion |
| drug metabolic process |
| positive regulation of multi-organism process |
| cellular response to lipid |
| regulation of hormone levels |
| anion transport |
| cytokine-mediated signaling pathway |
| response to bacterium |
| regulation of cytokine production |
| perinuclear region of cytoplasm |
| regulation of protein transport |
| protein localization to organelle |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of defense response |
| innate immune response |
| regulation of multi-organism process |
| regulation of secretion |
| response to lipid |
| protein homodimerization activity |
| peptidyl-amino acid modification |
| cellular homeostasis |
| carboxylic acid metabolic process |
| response to hormone |
| defense response to other organism |
| oxidation-reduction process |
| intracellular protein transport |
| regulation of catabolic process |
| oxoacid metabolic process |
| secretion by cell |
| cellular response to cytokine stimulus |
| response to drug |
| organic acid metabolic process |
| regulation of protein localization |
| export from cell |
| cellular response to oxygen-containing compound |
| organonitrogen compound catabolic process |
| regulation of response to external stimulus |
| response to cytokine |
| negative regulation of protein metabolic process |
| secretion |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| response to abiotic stimulus |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| ion transport |
| positive regulation of catalytic activity |
| response to endogenous stimulus |
| regulation of response to stress |
| protein transport |
| intracellular transport |
| peptide transport |
| response to oxygen-containing compound |
| amide transport |
| cellular protein localization |
| cellular macromolecule localization |
| establishment of protein localization |
| regulation of cell population proliferation |
| cellular nitrogen compound biosynthetic process |
| homeostatic process |
| intracellular signal transduction |
| negative regulation of gene expression |
| small molecule metabolic process |
| organic substance catabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of transport |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| CCT251545 20μM R07 exp326 | 1.87 |
| BML-284 0.09μM R08 exp460 | 2.15 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6535
- Expression level (log2 read counts): -3.02
Expression Distribution
NOS2 Expression in NALM6 Cells: -3.02
