NPAT

Entrez Summary: N/A
UniProt Summary: Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. {ECO:0000269|PubMed:10995386, ECO:0000269|PubMed:10995387, ECO:0000269|PubMed:12665581, ECO:0000269|PubMed:12724424, ECO:0000269|PubMed:14585971, ECO:0000269|PubMed:14612403, ECO:0000269|PubMed:15555599, ECO:0000269|PubMed:15988025, ECO:0000269|PubMed:16131487, ECO:0000269|PubMed:17163457, ECO:0000269|PubMed:17826007, ECO:0000269|PubMed:17967892, ECO:0000269|PubMed:17974976, ECO:0000269|PubMed:9472014}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 173/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	7/28
blood	6/28
bone	6/25
breast	9/33
central nervous system	11/56
cervix	0/4
colorectal	2/17
esophagus	2/13
fibroblast	1/1
gastric	2/15
kidney	5/21
liver	8/20
lung	11/75
lymphocyte	1/14
ovary	10/26
pancreas	4/24
peripheral nervous system	8/16
plasma cell	2/15
prostate	1/1
skin	9/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	5/22
urinary tract	2/29
uterus	1/5

Expression Distribution

Screen	Score
Thioridazine 5μM R08 exp530	1.79
Lenalidomide 20μM R07 exp375	2.04

Gemini of coiled bodies
regulation of transcription involved in G1/S transition of mitotic cell cycle
Cajal body
transcription coregulator activity
protein N-terminus binding
G1/S transition of mitotic cell cycle
cell cycle G1/S phase transition
protein C-terminus binding
transcription corepressor activity
mitotic cell cycle phase transition
cell cycle phase transition
transcription coactivator activity
in utero embryonic development
mitotic cell cycle process
chordate embryonic development
embryo development ending in birth or egg hatching
mitotic cell cycle
embryo development
cell cycle process
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
cell cycle
negative regulation of nucleobase-containing compound metabolic process
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of biosynthetic process
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process