NRF1

Entrez Summary: N/A
UniProt Summary: Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Bortezomib 0.05μM R00 exp7	-1.9
2-Methoxyestradiol 0.2μM R01 exp40	1.7
GSK591 2.6μM R03 exp128	1.82
AICAR 240μM R03 exp116	1.84
Tozasertib 0.1μM R07 exp414	1.85
Citral 50μM R06 exp274	1.94
Cytochalasin-B 5μM R07 exp349	2.05
UM0011500 10μM R05 exp246	2.06
Betulinic acid 10 to 15μM on day4 R05 exp222	2.08
Etoposide 0.1μM R05 exp198	2.3

Global Fraction of Cell Lines Where Essential: 497/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	21/28
blood	20/28
bone	17/26
breast	22/33
central nervous system	37/56
cervix	3/4
colorectal	12/17
esophagus	9/13
fibroblast	1/1
gastric	11/16
kidney	12/21
liver	8/20
lung	58/75
lymphocyte	12/16
ovary	18/26
pancreas	20/24
peripheral nervous system	12/16
plasma cell	8/15
prostate	0/1
skin	12/24
soft tissue	6/9
thyroid	1/2
upper aerodigestive	13/22
urinary tract	16/29
uterus	5/5

Expression Distribution

Nrf1 DNA-bind
Nrf1 activ bdg

core promoter sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
generation of precursor metabolites and energy
mitochondrion organization
DNA-binding transcription activator activity, RNA polymerase II-specific
RNA polymerase II proximal promoter sequence-specific DNA binding
protein homodimerization activity
positive regulation of transcription by RNA polymerase II
positive regulation of transcription, DNA-templated
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
positive regulation of RNA metabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression
positive regulation of biosynthetic process