NRG4

Entrez Summary: N/A
UniProt Summary: Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
A-196 10μM R03 exp114	1.71
Bortezomib 0.05μM R00 exp7	1.81

ERBB2 signaling pathway
ERBB signaling pathway
growth factor activity
positive regulation of protein kinase B signaling
regulation of protein kinase B signaling
signaling receptor binding
MAPK cascade
signal transduction by protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
enzyme linked receptor protein signaling pathway
regulation of cell motility
protein phosphorylation
regulation of locomotion
regulation of cellular component movement
positive regulation of intracellular signal transduction
phosphorylation
extracellular space
positive regulation of signal transduction
intracellular signal transduction
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction
extracellular region