NT5C3A

Entrez Summary: This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. Mutations in this gene are a cause of hemolytic anemia due to uridine 5-prime monophosphate hydrolase deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and pseudogenes of this gene are located on the long arm of chromosomes 3 and 4. [provided by RefSeq, Mar 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

HAD
UMPH-1

tRNA 2-phosphotransferase activity
5-nucleotidase activity
pyrimidine nucleoside catabolic process
nucleoside catabolic process
pyrimidine nucleoside metabolic process
pyrimidine-containing compound catabolic process
glycosyl compound catabolic process
nucleobase-containing small molecule catabolic process
nucleotide binding
pyrimidine-containing compound metabolic process
nucleoside metabolic process
glycosyl compound metabolic process
carbohydrate derivative catabolic process
defense response to virus
magnesium ion binding
response to virus
dephosphorylation
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
small molecule catabolic process
aromatic compound catabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process
organic cyclic compound catabolic process
nucleobase-containing small molecule metabolic process
organophosphate metabolic process
defense response to other organism
endoplasmic reticulum
carbohydrate derivative metabolic process
organonitrogen compound catabolic process
immune effector process
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
small molecule metabolic process
organic substance catabolic process
cellular catabolic process