NT5E

Entrez Summary: The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011].
UniProt Summary: Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities. {ECO:0000269|PubMed:21933152}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Metallophos
5 nucleotid C

adenosine biosynthetic process
AMP catabolic process
ribonucleoside monophosphate catabolic process
purine ribonucleoside monophosphate catabolic process
purine nucleoside monophosphate catabolic process
nucleoside monophosphate catabolic process
adenosine metabolic process
AMP metabolic process
5-nucleotidase activity
purine nucleoside biosynthetic process
pyrimidine nucleoside catabolic process
purine ribonucleoside biosynthetic process
ribonucleoside biosynthetic process
purine ribonucleotide catabolic process
ribonucleotide catabolic process
nucleoside catabolic process
pyrimidine nucleoside metabolic process
purine ribonucleoside monophosphate metabolic process
purine nucleoside monophosphate metabolic process
nucleoside biosynthetic process
glycosyl compound biosynthetic process
pyrimidine-containing compound catabolic process
glycosyl compound catabolic process
purine nucleotide catabolic process
NAD metabolic process
leukocyte cell-cell adhesion
ribonucleoside monophosphate metabolic process
nucleobase-containing small molecule catabolic process
purine-containing compound catabolic process
purine ribonucleoside metabolic process
nucleotide binding
purine nucleoside metabolic process
nucleotide catabolic process
nucleoside phosphate catabolic process
nucleoside monophosphate metabolic process
ribonucleoside metabolic process
anchored component of membrane
nucleobase-containing small molecule biosynthetic process
pyrimidine-containing compound metabolic process
nucleoside metabolic process